Relevance of multidrug resistance in the age of targeted therapy.

Türk, Dóra; Szakács, Gergely

Türk, Dóra; Szakács, Gergely.

Affiliation

Türk D; Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, 1113 Budapest, Karolina u. 29, Hungary.

Curr Opin Drug Discov Devel ; 12(2): 246-52, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19333870

Subject(s)

ATP-Binding Cassette Transporters/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Drug Design; Drug Resistance, Multiple/drug effects; Drug Resistance, Neoplasm/drug effects; Neoplasms/drug therapy; ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/metabolism; Drug Resistance, Multiple/genetics; Drug Resistance, Neoplasm/genetics; Gene Expression Regulation, Neoplastic; Genotype; Humans; Neoplasms/genetics; Neoplasms/metabolism; Phenotype; Protein Kinase Inhibitors/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Drug Resistance, Multiple / ATP-Binding Cassette Transporters / Drug Resistance, Neoplasm / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Curr Opin Drug Discov Devel Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2009 Document type: Article Affiliation country: Hungary Country of publication: United kingdom

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