Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.

Bénardeau, Agnes; Benz, Jörg; Binggeli, Alfred; Blum, Denise; Boehringer, Markus; Grether, Uwe; Hilpert, Hans; Kuhn, Bernd; Märki, Hans Peter; Meyer, Markus; Püntener, Kurt; Raab, Susanne; Ruf, Armin; Schlatter, Daniel; Mohr, Peter

Bénardeau, Agnes; Benz, Jörg; Binggeli, Alfred; Blum, Denise; Boehringer, Markus; Grether, Uwe; Hilpert, Hans; Kuhn, Bernd; Märki, Hans Peter; Meyer, Markus; Püntener, Kurt; Raab, Susanne; Ruf, Armin; Schlatter, Daniel; Mohr, Peter.

Affiliation

Bénardeau A; F. Hoffmann-La Roche Ltd, Pharma Research, CH-4070 Basel, Switzerland.

Bioorg Med Chem Lett ; 19(9): 2468-73, 2009 May 01.

Article in En | MEDLINE | ID: mdl-19349176

Subject(s)

Diabetes Mellitus, Type 2/drug therapy; Oxazoles/chemical synthesis; Oxazoles/pharmacology; PPAR alpha/agonists; PPAR gamma/agonists; Thiophenes/chemical synthesis; Thiophenes/pharmacology; Animals; Chemistry, Pharmaceutical/methods; Crystallography, X-Ray/methods; Drug Design; Dyslipidemias/drug therapy; Humans; Inhibitory Concentration 50; Ligands; Models, Chemical; Molecular Structure; Receptors, Cytoplasmic and Nuclear/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Thiophenes / PPAR alpha / PPAR gamma / Diabetes Mellitus, Type 2 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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