cAMP-mediated regulation of CYP enzymes and its application in chemotherapy.

Ishikawa, Yoshihiro; Suzuki, Sayaka; Otsu, Koji; Ulucan, Coskun; Iwatsubo, Kousaku; Eguchi, Haruki

Ishikawa, Yoshihiro; Suzuki, Sayaka; Otsu, Koji; Ulucan, Coskun; Iwatsubo, Kousaku; Eguchi, Haruki.

Affiliation

Ishikawa Y; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. yishikaw@med.yokohama-cu.ac.jp

Drug Metab Lett ; 1(3): 176-8, 2007 Aug.

Article in En | MEDLINE | ID: mdl-19356040

ABSTRACT

ABSTRACT

Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.

Subject(s)

Antineoplastic Agents/metabolism; Cytochrome P-450 Enzyme System/metabolism; Prodrugs/metabolism; Adenylyl Cyclases/metabolism; Animals; Antineoplastic Agents/therapeutic use; Cyclic AMP/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Enzyme Activators/pharmacology; Humans; Neoplasms/drug therapy; Phosphorylation; Prodrugs/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Cytochrome P-450 Enzyme System / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Drug Metab Lett Journal subject: FARMACOLOGIA / METABOLISMO Year: 2007 Document type: Article Affiliation country: Japan

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