4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.

Parmenon, Cécile; Guillard, Jérôme; Caignard, Daniel-Henri; Hennuyer, Nathalie; Staels, Bart; Audinot-Bouchez, Valérie; Boutin, Jean-Albert; Dacquet, Catherine; Ktorza, Alain; Viaud-Massuard, Marie-Claude

Parmenon, Cécile; Guillard, Jérôme; Caignard, Daniel-Henri; Hennuyer, Nathalie; Staels, Bart; Audinot-Bouchez, Valérie; Boutin, Jean-Albert; Dacquet, Catherine; Ktorza, Alain; Viaud-Massuard, Marie-Claude.

Affiliation

Parmenon C; UMR GICC, Laboratoire de Chimie Organique, UFR des Sciences Pharmaceutiques, Tours, France.

Bioorg Med Chem Lett ; 19(10): 2683-7, 2009 May 15.

Article in En | MEDLINE | ID: mdl-19376700

Subject(s)

Oximes/chemistry; PPAR alpha/agonists; PPAR gamma/agonists; Quinolines/chemical synthesis; Quinolines/pharmacology; Animals; Cell Line; Diabetes Mellitus, Type 2/drug therapy; Disease Models, Animal; Humans; Mice; PPAR alpha/metabolism; PPAR gamma/metabolism; Quinolines/chemistry; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Quinolines / PPAR alpha / PPAR gamma Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: France Country of publication: United kingdom

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