Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site.

Trivedi, Vishal; Boire, Adrienne; Tchernychev, Boris; Kaneider, Nicole C; Leger, Andrew J; O'Callaghan, Katie; Covic, Lidija; Kuliopulos, Athan

Trivedi, Vishal; Boire, Adrienne; Tchernychev, Boris; Kaneider, Nicole C; Leger, Andrew J; O'Callaghan, Katie; Covic, Lidija; Kuliopulos, Athan.

Affiliation

Trivedi V; Department of Medicine, Tufts University School of Medicine, Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

Cell ; 137(2): 332-43, 2009 Apr 17.

Article in En | MEDLINE | ID: mdl-19379698

Subject(s)

Receptor, PAR-1/metabolism; Thrombosis/metabolism; Animals; Blood Platelets/metabolism; Collagen/metabolism; GTP-Binding Proteins/metabolism; Guinea Pigs; Humans; Ligands; Matrix Metalloproteinase 1/metabolism; Protein Structure, Tertiary; Receptor, PAR-1/chemistry; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Receptor, PAR-1 Limits: Animals / Humans Language: En Journal: Cell Year: 2009 Document type: Article Affiliation country: United States

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