Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Hay, Trevor; Matthews, James R; Pietzka, Lucie; Lau, Alan; Cranston, Aaron; Nygren, Anders O H; Douglas-Jones, Anthony; Smith, Graeme C M; Martin, Niall M B; O'Connor, Mark; Clarke, Alan R

Hay, Trevor; Matthews, James R; Pietzka, Lucie; Lau, Alan; Cranston, Aaron; Nygren, Anders O H; Douglas-Jones, Anthony; Smith, Graeme C M; Martin, Niall M B; O'Connor, Mark; Clarke, Alan R.

Affiliation

Hay T; Department of Genetics, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Cancer Res ; 69(9): 3850-5, 2009 May 01.

Article in En | MEDLINE | ID: mdl-19383921

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Genes, BRCA2; Genes, p53; Mammary Neoplasms, Experimental/drug therapy; Mammary Neoplasms, Experimental/genetics; Poly(ADP-ribose) Polymerase Inhibitors; Animals; BRCA2 Protein/deficiency; BRCA2 Protein/genetics; Carboplatin/administration & dosage; Disease Models, Animal; Female; Mammary Neoplasms, Experimental/enzymology; Mice; Mice, Transgenic; Mutation; Phthalazines/administration & dosage; Piperazines/administration & dosage; Poly (ADP-Ribose) Polymerase-1; Tumor Suppressor Protein p53/deficiency; Tumor Suppressor Protein p53/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Genes, p53 / Genes, BRCA2 / Poly(ADP-ribose) Polymerase Inhibitors / Mammary Neoplasms, Experimental Limits: Animals Language: En Journal: Cancer Res Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United States

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