DRDE-07 and its analogues as promising cytoprotectants to nitrogen mustard (HN-2)--an alkylating anticancer and chemical warfare agent.

Sharma, Manoj; Vijayaraghavan, R; Gautam, Anshoo

Sharma, Manoj; Vijayaraghavan, R; Gautam, Anshoo.

Affiliation

Sharma M; Defence Research and Development Establishment, Jhansi Road, Gwalior, India.

Toxicol Lett ; 188(3): 243-50, 2009 Aug 10.

Article in En | MEDLINE | ID: mdl-19397960

Subject(s)

Amifostine/analogs & derivatives; Antidotes/therapeutic use; Antineoplastic Agents, Alkylating/toxicity; Chemical Warfare Agents/toxicity; Mechlorethamine/toxicity; Amifostine/chemistry; Amifostine/therapeutic use; Animals; Antidotes/chemistry; Body Weight/drug effects; Cytoprotection; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions/pathology; Drug-Related Side Effects and Adverse Reactions/prevention & control; Female; Lethal Dose 50; Mice; Molecular Weight; Organ Size/drug effects; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemical Warfare Agents / Amifostine / Antineoplastic Agents, Alkylating / Mechlorethamine / Antidotes Limits: Animals Language: En Journal: Toxicol Lett Year: 2009 Document type: Article Affiliation country: India Country of publication: Netherlands

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