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Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.
Banu, Sakhila K; Lee, JeHoon; Speights, V O; Starzinski-Powitz, Anna; Arosh, Joe A.
Affiliation
  • Banu SK; Reproductive Endocrinology and Cell Signaling Laboratory, Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77843, USA.
Mol Endocrinol ; 23(8): 1291-305, 2009 Aug.
Article in En | MEDLINE | ID: mdl-19407222
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Apoptosis / Receptors, Prostaglandin E / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Endometrium / Proto-Oncogene Proteins c-akt / Beta Catenin Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Apoptosis / Receptors, Prostaglandin E / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Endometrium / Proto-Oncogene Proteins c-akt / Beta Catenin Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States