Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells.
J Asian Nat Prod Res
; 11(4): 294-8, 2009.
Article
in En
| MEDLINE
| ID: mdl-19431008
ABSTRACT
A new sesquiterpene lactone glucoside, 11,13-dihydroixerinoside (1), together with the five known sesquiterpene lactones, ixerinoside (2), ixerin Z (3), 11,13alpha-dihydroixerin Z (4), ixerin Z1 (5), and 3-hydroxydehydroleucodin (6), respectively, were isolated from the whole plants of Ixeris sonchifolia Hance. The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. When the in vitro cytotoxic activities of compounds 1-6 were evaluated against A549 human non-small cell lung cancer cells, all six compounds exhibited cytotoxic activity against A549 cells, with compounds 2, 3, and 6 showing good activities (inhibitory concentration (IC(50) values < 30 microg/ml) that are comparable with well-established chemotherapeutic drug, 5-fluorouracil.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Sesquiterpenes
/
Asteraceae
/
Glucosides
/
Lactones
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2009
Document type:
Article
Affiliation country:
Singapore