Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.

Zhou, Changcheng; King, Nakesha; Chen, Kwan Y; Breslow, Jan L

Zhou, Changcheng; King, Nakesha; Chen, Kwan Y; Breslow, Jan L.

Affiliation

Zhou C; Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA.

J Lipid Res ; 50(10): 2004-13, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19436068

Subject(s)

Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/chemically induced; Hypercholesterolemia/chemically induced; Receptors, Steroid/metabolism; Animals; CD36 Antigens/metabolism; Hep G2 Cells; Humans; Lipoproteins, LDL/metabolism; Lipoproteins, VLDL/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Pregnane X Receptor; Receptors, Steroid/agonists

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoproteins E / Receptors, Steroid / Atherosclerosis / Hypercholesterolemia Limits: Animals / Humans Language: En Journal: J Lipid Res Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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