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An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.
Ozaki, Ken-ichi; Onoma, Mitsu; Muramatsu, Hiroyasu; Sudo, Hirokazu; Yoshida, Shoshin; Shiokawa, Rie; Yogo, Kenji; Kamei, Kenshi; Cynshi, Osamu; Kuromaru, Osamu; Peeters, Theo L; Takanashi, Hisanori.
Affiliation
  • Ozaki K; Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan. ozakikni@chugai-pharm.co.jp
Eur J Pharmacol ; 615(1-3): 185-92, 2009 Aug 01.
Article in En | MEDLINE | ID: mdl-19445919
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Receptors, Gastrointestinal Hormone / Receptors, Neuropeptide / Diarrhea / Gastric Fundus / Gastrointestinal Motility / Muscle Tonus Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2009 Document type: Article Affiliation country: Japan Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Receptors, Gastrointestinal Hormone / Receptors, Neuropeptide / Diarrhea / Gastric Fundus / Gastrointestinal Motility / Muscle Tonus Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2009 Document type: Article Affiliation country: Japan Country of publication: Netherlands