Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways.
Virus Res
; 144(1-2): 225-32, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19447147
ABSTRACT
Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked alpha2-3 and alpha2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyl alpha 2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyl alpha 2-3Gal glycans. In the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen Sialyl alpha 2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyl alpha 2-3 and Sialyl alpha 2-6 epitopes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sialic Acids
/
Respiratory Mucosa
/
Influenza A Virus, H1N1 Subtype
Limits:
Animals
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2009
Document type:
Article
Affiliation country:
Denmark
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS