Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy.

Goyenvalle, Aurélie; Babbs, Arran; van Ommen, Gert-Jan B; Garcia, Luis; Davies, Kay E

Goyenvalle, Aurélie; Babbs, Arran; van Ommen, Gert-Jan B; Garcia, Luis; Davies, Kay E.

Affiliation

Goyenvalle A; Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

Mol Ther ; 17(7): 1234-40, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19455105

Subject(s)

RNA, Small Nuclear/genetics; Animals; Blotting, Western; Cell Line; Cells, Cultured; Dystrophin; Exons/genetics; Genetic Therapy/methods; Genetic Vectors/genetics; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics; Humans; Mice; Mice, Transgenic; Models, Biological; Muscular Dystrophy, Duchenne/therapy; Myoblasts/metabolism; NIH 3T3 Cells; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Small Nuclear Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United States

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