Chemokine IP-10: an adjunct marker for latent tuberculosis infection in children.
Int J Tuberc Lung Dis
; 13(6): 731-6, 2009 Jun.
Article
in En
| MEDLINE
| ID: mdl-19460249
ABSTRACT
SETTING:
Recent reports indicate a role of chemokine inducible protein 10 (IP-10) in Mycobacterium tuberculosis infection substantiated by the detection of elevated levels in plasma and at infection foci in individuals infected with M. tuberculosis.OBJECTIVE:
To evaluate IP-10 as a potential marker for the diagnosis of M. tuberculosis infection in children living in a region of low tuberculosis (TB) prevalence.DESIGN:
IP-10 levels were obtained after whole blood stimulation with M. tuberculosis-specific antigens in 127 children. IP-10 results were evaluated upon gradations of exposure risk to M. tuberculosis and correlation with tuberculin skin test and an interferon-gamma release assay (IGRA).RESULTS:
IP-10 reactivity correlated well to risk of exposure to M. tuberculosis in children. There was a strong correlation between IP-10 and IGRA results. IP-10 responses, unlike interferon-gamma (IFN-gamma), were not age-dependent and detected more positive results in children aged <5 years. In the children with active disease, the IGRA was more sensitive than IP-10 at detecting M. tuberculosis infection.CONCLUSION:
Our findings suggest that IP-10 in combination with IFN-gamma may enhance the diagnostic performance of IGRAs in detecting M. tuberculosis infection, especially in young children.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
/
Biomarkers
/
Chemokine CXCL10
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
Int J Tuberc Lung Dis
Year:
2009
Document type:
Article
Affiliation country:
United States