Combined homology modelling and evolutionary significance evaluation of missense mutations in blood clotting factor VIII to highlight aspects of structure and function.

Markoff, A; Gerke, V; Bogdanova, N

Markoff, A; Gerke, V; Bogdanova, N.

Affiliation

Markoff A; Institut für Medizinische Biochemie, ZMBE, WWU Münster, Von Esmarch Str. 56, Münster 48149, Germany. markoff@uni-muenster.de

Haemophilia ; 15(4): 932-41, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19473423

Subject(s)

Factor VIII/genetics; Hemophilia A/genetics; Mutation, Missense/genetics; Phenotype; Factor VIII/ultrastructure; Hemophilia A/physiopathology; Humans; Male; Models, Molecular; Molecular Sequence Data; Mutation, Missense/physiology; Predictive Value of Tests; Sequence Homology, Amino Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Factor VIII / Mutation, Missense / Hemophilia A Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Haemophilia Journal subject: HEMATOLOGIA Year: 2009 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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