Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits.

Minatoguchi, Shinya; Zhang, Zengi; Bao, Narentuoya; Kobayashi, Hiroyuki; Yasuda, Shinji; Iwasa, Masamitsu; Sumi, Syouhei; Kawamura, Itta; Yamada, Yoshihisa; Nishigaki, Kazuhiko; Takemura, Genzou; Fujiwara, Takako; Fujiwara, Hisayoshi

Minatoguchi, Shinya; Zhang, Zengi; Bao, Narentuoya; Kobayashi, Hiroyuki; Yasuda, Shinji; Iwasa, Masamitsu; Sumi, Syouhei; Kawamura, Itta; Yamada, Yoshihisa; Nishigaki, Kazuhiko; Takemura, Genzou; Fujiwara, Takako; Fujiwara, Hisayoshi.

Affiliation

Minatoguchi S; Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501-1194, Gifu 500, Japan. minatos@gifu-u.ac.jp

J Cardiovasc Pharmacol ; 54(1): 25-30, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19487955

Subject(s)

Acarbose/therapeutic use; Hydroxyl Radical/metabolism; Hyperglycemia/drug therapy; Myocardial Infarction/drug therapy; Potassium Channels/metabolism; Animals; Blood Glucose/analysis; Catechols/metabolism; Enzyme Inhibitors/therapeutic use; Gentisates/metabolism; Hydroxybenzoates/metabolism; Male; Rabbits

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium Channels / Hydroxyl Radical / Acarbose / Hyperglycemia / Myocardial Infarction Limits: Animals Language: En Journal: J Cardiovasc Pharmacol Year: 2009 Document type: Article Affiliation country: Japan Country of publication: United States

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