Dynamic kinetic resolution of N-benzoyl-DL-amino acids via peptide bond forming reactions.
Protein Pept Lett
; 17(4): 419-22, 2010 Apr.
Article
in En
| MEDLINE
| ID: mdl-19508192
ABSTRACT
Dynamic kinetic resolution (DKR) was demonstrated in the carbodiimide-mediated couplings of N-benzoyl-DL-amino acids with L-amino acid esters the yields of the D-L-peptides significantly exceeded 50% in some cases. N-Benzoyl-DL-t-leucine afforded the D-L-peptide almost exclusively (up to 96% yield) in the reaction with methyl L-prolinate, which is the most efficient DKR obtained in the field of amino acids and derivatives.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzoates
/
Dipeptides
/
Amino Acids
Language:
En
Journal:
Protein Pept Lett
Journal subject:
BIOQUIMICA
Year:
2010
Document type:
Article