Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population.

Blanco, Belén; Pérez-Simón, José A; Sánchez-Abarca, Luis I; Caballero-Velazquez, Teresa; Gutierrez-Cossío, Silvia; Hernández-Campo, Pilar; Díez-Campelo, María; Herrero-Sanchez, Carmen; Rodriguez-Serrano, Concepción; Santamaría, Carlos; Sánchez-Guijo, Fermín M; Del Cañizo, Consuelo; San Miguel, Jesús F

Blanco, Belén; Pérez-Simón, José A; Sánchez-Abarca, Luis I; Caballero-Velazquez, Teresa; Gutierrez-Cossío, Silvia; Hernández-Campo, Pilar; Díez-Campelo, María; Herrero-Sanchez, Carmen; Rodriguez-Serrano, Concepción; Santamaría, Carlos; Sánchez-Guijo, Fermín M; Del Cañizo, Consuelo; San Miguel, Jesús F.

Affiliation

Blanco B; Servicio de Hematología y CIC Salamanca, Hospital Universitario de Salamanca and Centro de Investigación del Cáncer Salamanca, Centro en Red de Medicina Regenerativa y Terapia celular de Castilla y León, Spain.

Haematologica ; 94(7): 975-83, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19508976

Subject(s)

Boronic Acids/pharmacology; Lymphocyte Subsets/drug effects; Pyrazines/pharmacology; T-Lymphocytes/drug effects; Antineoplastic Agents/pharmacology; Bortezomib; CD28 Antigens/biosynthesis; CD3 Complex/biosynthesis; CD4-Positive T-Lymphocytes/cytology; Cell Proliferation; Coculture Techniques; Humans; Interleukin-2/metabolism; Interleukin-2 Receptor alpha Subunit/biosynthesis; Leukocytes, Mononuclear/metabolism; Phenotype; Proteasome Inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Boronic Acids / T-Lymphocytes / Lymphocyte Subsets Limits: Humans Language: En Journal: Haematologica Year: 2009 Document type: Article Affiliation country: Spain Country of publication: Italy

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