Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.

Irungu, Beatrice; Kiboi, Daniel; Langat, Bernard; Rukunga, Geoffrey; Wittlin, Sergio; Nzila, Alexis

Irungu, Beatrice; Kiboi, Daniel; Langat, Bernard; Rukunga, Geoffrey; Wittlin, Sergio; Nzila, Alexis.

Affiliation

Irungu B; Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Nairobi City Square, Kenya.

Exp Parasitol ; 123(2): 118-21, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19527714

Subject(s)

Aminopterin/pharmacology; Enzyme Inhibitors/pharmacology; Folic Acid Antagonists/pharmacology; Methotrexate/pharmacology; Plasmodium/drug effects; Administration, Oral; Aminopterin/administration & dosage; Aminopterin/pharmacokinetics; Animals; Biological Availability; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacokinetics; Female; Folic Acid/administration & dosage; Folic Acid/pharmacology; Folic Acid Antagonists/administration & dosage; Folic Acid Antagonists/pharmacokinetics; Malaria/drug therapy; Malaria/parasitology; Methotrexate/administration & dosage; Methotrexate/pharmacokinetics; Mice; Plasmodium/classification; Plasmodium berghei/drug effects; Plasmodium chabaudi/drug effects; Plasmodium yoelii/drug effects; Pyrimethamine/administration & dosage; Pyrimethamine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium / Methotrexate / Enzyme Inhibitors / Folic Acid Antagonists / Aminopterin Limits: Animals Language: En Journal: Exp Parasitol Year: 2009 Document type: Article Affiliation country: Kenya

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