KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2).

Ky, Nung; Lim, Chuan Bian; Li, Jinming; Tam, James P; Hamza, Mohamed Sabry; Zhao, Yan

Ky, Nung; Lim, Chuan Bian; Li, Jinming; Tam, James P; Hamza, Mohamed Sabry; Zhao, Yan.

Affiliation

Ky N; Nanyang Technological University, Singapore, Singapore.

Apoptosis ; 14(9): 1095-107, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19544095

Subject(s)

Caspases/metabolism; Cyclin-Dependent Kinase Inhibitor p57/metabolism; Histone Deacetylase Inhibitors; Hydroxamic Acids/pharmacology; Kruppel-Like Transcription Factors/metabolism; MAP Kinase Signaling System/drug effects; Mitogen-Activated Protein Kinases/metabolism; Apoptosis/drug effects; Cyclin-Dependent Kinase Inhibitor p57/genetics; Cytoprotection/drug effects; Enzyme Activation/drug effects; HCT116 Cells; Humans; Kruppel-Like Factor 4; Oligopeptides/pharmacology; Phosphorylation/drug effects; Promoter Regions, Genetic/genetics; Protein Binding/drug effects; Vorinostat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspases / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Cyclin-Dependent Kinase Inhibitor p57 / Kruppel-Like Transcription Factors / Histone Deacetylase Inhibitors / Hydroxamic Acids Limits: Humans Language: En Journal: Apoptosis Year: 2009 Document type: Article Affiliation country: Singapore Country of publication: Netherlands

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