Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase.
Prostate Cancer Prostatic Dis
; 13(1): 39-46, 2010 Mar.
Article
in En
| MEDLINE
| ID: mdl-19546883
ABSTRACT
Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22(phox) and gp91(phox) subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Radiation-Sensitizing Agents
/
Oxidative Stress
/
NADPH Oxidases
/
Androgen Antagonists
/
Androgens
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Prostate Cancer Prostatic Dis
Journal subject:
ENDOCRINOLOGIA
/
NEOPLASIAS
/
UROLOGIA
Year:
2010
Document type:
Article
Affiliation country:
Canada