[Chloroquine cardiotoxicity in long-term lupus therapy in two patients]. / Cardiotoxicité après un traitement au long cours par chloroquine chez deux patientes lupiques.
Ann Dermatol Venereol
; 136(6-7): 530-5, 2009.
Article
in Fr
| MEDLINE
| ID: mdl-19560616
ABSTRACT
BACKGROUND:
The antimalarial compounds chloroquine and hydroxychloroquine are widely used in the treatment of connective tissue diseases and are usually well tolerated. We report two cases of chloroquine cardiotoxicity. PATIENTS ANDMETHODS:
Two women (aged 43 and 48 years) were treated for 5 years for lupus. They developed severe conduction disturbances requiring a pacemaker. Plasma chloroquine concentrations were abnormally high in both cases. In one case, a genetic polymorphism modulating the activity of a cytochrome involved in chloroquine metabolism (CYP2C8) was identified.DISCUSSION:
Since 1965, 60 cases of occasionally severe cardiotoxicity have been reported following long-term treatment with chloroquine in most cases, but also with hydroxychloroquine. This toxicity must be detected early and close cardiac assessment is required.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chloroquine
/
Ventricular Dysfunction
/
Antirheumatic Agents
/
Atrioventricular Block
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
Fr
Journal:
Ann Dermatol Venereol
Year:
2009
Document type:
Article
Affiliation country:
France