PDE10A inhibitors: an assessment of the current CNS drug discovery landscape.

Chappie, Tom; Humphrey, John; Menniti, Frank; Schmidt, Chris

Chappie, Tom; Humphrey, John; Menniti, Frank; Schmidt, Chris.

Affiliation

Chappie T; Pfizer Inc, Neuroscience Medicinal Chemistry, Groton, CT 06340, USA. thomas.a.chappie@pfizer.com

Curr Opin Drug Discov Devel ; 12(4): 458-67, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19562642

Subject(s)

Antipsychotic Agents/pharmacology; Drug Discovery; Phosphodiesterase Inhibitors/pharmacology; Phosphoric Diester Hydrolases/metabolism; Animals; Antipsychotic Agents/chemistry; Antipsychotic Agents/therapeutic use; Basal Ganglia/drug effects; Basal Ganglia/enzymology; Humans; Ligands; Models, Molecular; Molecular Structure; Neurons/drug effects; Neurons/enzymology; Phosphodiesterase Inhibitors/chemistry; Phosphodiesterase Inhibitors/therapeutic use; Protein Binding; Schizophrenia/drug therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Antipsychotic Agents / Phosphoric Diester Hydrolases / Drug Discovery Limits: Animals / Humans Language: En Journal: Curr Opin Drug Discov Devel Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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