Long-term benefits after treatment of traumatic brain injury with simvastatin in rats.

Mahmood, Asim; Goussev, Anton; Kazmi, Humaira; Qu, Changsheng; Lu, Dunyue; Chopp, Michael

Mahmood, Asim; Goussev, Anton; Kazmi, Humaira; Qu, Changsheng; Lu, Dunyue; Chopp, Michael.

Affiliation

Mahmood A; Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA. nsaam@neuro.hfh.edu

Neurosurgery ; 65(1): 187-91; discussion 191-2, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19574841

Subject(s)

Brain Injuries/drug therapy; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Simvastatin/therapeutic use; Animals; Brain Injuries/pathology; Brain-Derived Neurotrophic Factor/metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay/methods; Female; Hippocampus/pathology; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Neurons/drug effects; Neurons/pathology; Rats; Rats, Wistar; Simvastatin/pharmacology; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurosurgery Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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