Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid dispersions.
Pharm Dev Technol
; 15(2): 162-8, 2010.
Article
in En
| MEDLINE
| ID: mdl-19589124
ABSTRACT
Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drugcarrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Carriers
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
/
Povidone
Language:
En
Journal:
Pharm Dev Technol
Journal subject:
FARMACIA
Year:
2010
Document type:
Article
Affiliation country:
Argentina