Neuropathogenic and non-neuropathogenic genotypes of Equid Herpesvirus type 1 in Argentina.
Vet Microbiol
; 139(3-4): 361-4, 2009 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-19589651
ABSTRACT
Infection with Equid Herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurological disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism (A(2254)/G(2254)) in the genome region of the open reading frame 30 (ORF30), which results in an amino acid variation (N(752)/D(752)) of the EHV-1 DNA polymerase, is significantly associated with the neuropathogenic potential of naturally occurring strains. In order to estimate the prevalence of the EHV-1 neuropathogenic genotype in our country, we analyzed the ORF30 genome region of Argentinean EHV-1 isolates. The study was carried out by real time allelic discrimination PCR in 90 equine EHV-1-positive samples, being 89 from 54 cases of abortion outbreaks (two of which were in association with neurological disease) and one from the respiratory tract of a healthy horse in training. Our results indicate that 7% (4/54) of the abortion outbreaks studied were induced by the neuropathogenic (G(2254)) genotype of EHV-1 and 50% (2/4) of them were associated with simultaneous neurological disease. This information emphasizes the necessity to extreme the hygienic and preventive measures to diminish EHV-1 infections and consequently reduce the risk of epizootic neurological disease as has been recently observed in other countries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Herpesvirus 1, Equid
/
Herpesviridae Infections
/
Horse Diseases
Type of study:
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Country/Region as subject:
America do sul
/
Argentina
Language:
En
Journal:
Vet Microbiol
Year:
2009
Document type:
Article
Affiliation country:
Argentina