Your browser doesn't support javascript.
loading
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Lucas, Matthew C; Carter, David S; Cai, Hai-Ying; Lee, Eun Kyung; Schoenfeld, Ryan C; Steiner, Sandra; Villa, Marzia; Weikert, Robert J; Iyer, Pravin S.
Affiliation
  • Lucas MC; Roche Palo Alto LLC, Palo Alto, CA 94304, USA. matthew.lucas@roche.com
Bioorg Med Chem Lett ; 19(16): 4630-3, 2009 Aug 15.
Article in En | MEDLINE | ID: mdl-19592243
ABSTRACT
A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurotransmitter Uptake Inhibitors / Cytochrome P-450 CYP2D6 Inhibitors / Cytochrome P-450 CYP3A Inhibitors / Heterocyclic Compounds Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurotransmitter Uptake Inhibitors / Cytochrome P-450 CYP2D6 Inhibitors / Cytochrome P-450 CYP3A Inhibitors / Heterocyclic Compounds Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States