In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.

Osborne, Colin S; Neckermann, Georg; Fischer, Evelin; Pecanka, Robert; Yu, Donghui; Manni, Kari; Goldovitz, Julie; Amaral, Kerri; Dzink-Fox, JoAnn; Ryder, Neil S

Osborne, Colin S; Neckermann, Georg; Fischer, Evelin; Pecanka, Robert; Yu, Donghui; Manni, Kari; Goldovitz, Julie; Amaral, Kerri; Dzink-Fox, JoAnn; Ryder, Neil S.

Affiliation

Osborne CS; Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA. colin.osborne@novartis.com

Antimicrob Agents Chemother ; 53(9): 3777-81, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19596876

Subject(s)

Amidohydrolases/antagonists & inhibitors; Anti-Infective Agents/pharmacology; Anti-Infective Agents/therapeutic use; Peptides/pharmacology; Peptides/therapeutic use; Pneumonia/drug therapy; Staphylococcus aureus/drug effects; Acetamides/pharmacokinetics; Acetamides/pharmacology; Acetamides/therapeutic use; Animals; Anti-Infective Agents/pharmacokinetics; Female; Linezolid; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones/pharmacokinetics; Oxazolidinones/pharmacology; Oxazolidinones/therapeutic use; Peptides/pharmacokinetics; Pneumonia/microbiology; Streptococcus pneumoniae/drug effects; Thigh/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Pneumonia / Staphylococcus aureus / Amidohydrolases / Anti-Infective Agents Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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