Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.

Johnston, Robert J; Poholek, Amanda C; DiToro, Daniel; Yusuf, Isharat; Eto, Danelle; Barnett, Burton; Dent, Alexander L; Craft, Joe; Crotty, Shane

Johnston, Robert J; Poholek, Amanda C; DiToro, Daniel; Yusuf, Isharat; Eto, Danelle; Barnett, Burton; Dent, Alexander L; Craft, Joe; Crotty, Shane.

Affiliation

Johnston RJ; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology (LIAI), 9420 Athena Circle, La Jolla, CA 92037, USA.

Science ; 325(5943): 1006-10, 2009 Aug 21.

Article in En | MEDLINE | ID: mdl-19608860

Subject(s)

DNA-Binding Proteins/metabolism; T-Lymphocyte Subsets/immunology; T-Lymphocytes, Helper-Inducer/immunology; Transcription Factors/metabolism; Animals; Antibody Formation; Arenaviridae Infections/immunology; B-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; Cell Differentiation; Cell Lineage; Cytokines/metabolism; DNA-Binding Proteins/genetics; Gene Expression Regulation; Germinal Center/cytology; Germinal Center/immunology; Lymphocyte Activation; Lymphocytic choriomeningitis virus/immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Positive Regulatory Domain I-Binding Factor 1; Proto-Oncogene Proteins c-bcl-6; RNA, Messenger/genetics; RNA, Messenger/metabolism; Signal Transduction; T-Lymphocyte Subsets/cytology; T-Lymphocytes, Helper-Inducer/cytology; Transcription Factors/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / T-Lymphocyte Subsets / T-Lymphocytes, Helper-Inducer / DNA-Binding Proteins Limits: Animals Language: En Journal: Science Year: 2009 Document type: Article Affiliation country: United States

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