Molecular epidemiology of H5N1 avian influenza.
Rev Sci Tech
; 28(1): 39-47, 2009 Apr.
Article
in En
| MEDLINE
| ID: mdl-19618617
ABSTRACT
The highly pathogenic Asian H5N1 influenza virus that was first detected in Guangdong in the People's Republic of China (China) in 1996 is unique in having spread to humans and other mammalian species. To date, this virus has not consistently transmitted between any mammalian species but the continued spread and evolution of these viruses in domestic poultry across Eurasia presents a continuing pandemic threat. These viruses have caused devastation in domestic poultry and have killed over 60% of infected humans. The H5N1 viruses are unique in having evolved into multiple clades and subclades by reassortment with other influenza viruses in the epicentre of southern China, and accumulation of point mutations has resulted in antigenic differences between the clades. Three waves of spread have occurred, wave one to East Asia and Southeast Asia, wave two through Qinghai Lake, China, to Europe, India and Africa, and wave three to Southeast Asia again. This paper deals with the molecular epidemiology of the evolution of the multiplicity of H5N1 clades. The continuing evolution of these H5N1 viruses and the possible establishment of secondary epicentres in Indonesia, Egypt and Nigeria present a continuing threat to poultry and people globally.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
/
Influenza in Birds
Type of study:
Screening_studies
Limits:
Animals
/
Humans
Country/Region as subject:
Africa
/
Asia
/
Europa
Language:
En
Journal:
Rev Sci Tech
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MEDICINA VETERINARIA
Year:
2009
Document type:
Article
Affiliation country:
China