Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.

Kim, Kyung-Hee; Wissner, Allan; Floyd, Middleton B; Fraser, Heidi L; Wang, Yanong D; Dushin, Russell G; Hu, Yongbo; Olland, Andrea; Guo, Bing; Arndt, Kim

Kim, Kyung-Hee; Wissner, Allan; Floyd, Middleton B; Fraser, Heidi L; Wang, Yanong D; Dushin, Russell G; Hu, Yongbo; Olland, Andrea; Guo, Bing; Arndt, Kim.

Affiliation

Kim KH; Wyeth Research, Chemical Sciences, 401 N. Middletown Road, Pearl River, NY 10965, USA. kimk@wyeth.com

Bioorg Med Chem Lett ; 19(17): 5225-8, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19628388

Subject(s)

Antineoplastic Agents/chemistry; Naphthyridines/chemistry; Protein Kinase Inhibitors/chemistry; Protein Serine-Threonine Kinases/antagonists & inhibitors; 3-Phosphoinositide-Dependent Protein Kinases; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Binding Sites; Crystallography, X-Ray; Humans; Molecular Conformation; Naphthyridines/chemical synthesis; Naphthyridines/pharmacology; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / Naphthyridines / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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