Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator.

Auyeung-Kim, Diana J; Devalaraja, Madhav N; Migone, Thi-Sau; Cai, Wendy; Chellman, Gary J

Auyeung-Kim, Diana J; Devalaraja, Madhav N; Migone, Thi-Sau; Cai, Wendy; Chellman, Gary J.

Affiliation

Auyeung-Kim DJ; Charles River Preclinical Services Nevada, 6995 Longley Lane, Reno, NV 89511, USA. diana.auyeung-kim@crl.com

Reprod Toxicol ; 28(4): 443-55, 2009 Dec.

Article in En | MEDLINE | ID: mdl-19631735

Subject(s)

Antibodies, Monoclonal/pharmacology; B-Cell Activating Factor/immunology; Fetus/drug effects; Macaca fascicularis/embryology; Macaca fascicularis/growth & development; Animals; Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal, Humanized; Area Under Curve; B-Lymphocytes/drug effects; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Immunosuppressive Agents/immunology; Immunosuppressive Agents/pharmacology; Lymphocyte Activation/drug effects; Maternal-Fetal Exchange/drug effects; Maternal-Fetal Exchange/immunology; Metabolic Clearance Rate; Pregnancy; Time Factors

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Cell Activating Factor / Fetus / Macaca fascicularis / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google