4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5071-4, 2009 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-19632113
ABSTRACT
A series of 4-anilino-7-pyridyl-3-quinolinecarbonitriles was prepared as Src kinase inhibitors. A systematic SAR study of substitutions on both the pyridine ring and the 3-quinolinecarbonitrile core established the requirements for optimal activity. The lead compound, 17, showed potent activity in both the Src enzyme assay and cell assays, and demonstrated in vivo anti-tumor activity in a xenograft model.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Src-Family Kinases
/
Protein Kinase Inhibitors
/
Aminoquinolines
/
Aniline Compounds
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2009
Document type:
Article
Affiliation country:
United States