Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

Woolson, Hayley D; Thomson, Victoria S; Rutherford, Claire; Yarwood, Stephen J; Palmer, Timothy M

Woolson, Hayley D; Thomson, Victoria S; Rutherford, Claire; Yarwood, Stephen J; Palmer, Timothy M.

Affiliation

Woolson HD; Biochemistry and Cell Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

Cell Signal ; 21(11): 1706-15, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19632320

Subject(s)

Cyclic AMP/metabolism; Cytokines/pharmacology; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Guanine Nucleotide Exchange Factors/metabolism; Suppressor of Cytokine Signaling Proteins/metabolism; CCAAT-Enhancer-Binding Protein-beta/metabolism; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases/metabolism; Endothelial Cells/metabolism; Extracellular Signal-Regulated MAP Kinases/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Knockdown Techniques; Humans; Interleukin-6/pharmacology; Interleukin-6 Receptor alpha Subunit/metabolism; Leptin/pharmacology; Phosphorylation; RNA, Small Interfering/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins/antagonists & inhibitors; Suppressor of Cytokine Signaling Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Cyclic AMP / Guanine Nucleotide Exchange Factors / Extracellular Signal-Regulated MAP Kinases / Suppressor of Cytokine Signaling Proteins Limits: Humans Language: En Journal: Cell Signal Year: 2009 Document type: Article Affiliation country: United kingdom

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