Design and optimisation of potent gp120-CD4 inhibitors.

Tran, Thien-Duc; Adam, Fiona M; Calo, Frederick; Fenwick, David R; Fok-Seang, Juin; Gardner, Iain; Hay, Duncan A; Perros, Manos; Rawal, Jaiessh; Middleton, Donald S; Parkinson, Tanya; Pickford, Christopher; Platts, Michelle; Randall, Amy; Stephenson, Peter T; Vuong, Hannah; Williams, David H

Tran, Thien-Duc; Adam, Fiona M; Calo, Frederick; Fenwick, David R; Fok-Seang, Juin; Gardner, Iain; Hay, Duncan A; Perros, Manos; Rawal, Jaiessh; Middleton, Donald S; Parkinson, Tanya; Pickford, Christopher; Platts, Michelle; Randall, Amy; Stephenson, Peter T; Vuong, Hannah; Williams, David H.

Affiliation

Tran TD; Discovery Chemistry, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent, UK. thien.tran@pfizer.com

Bioorg Med Chem Lett ; 19(17): 5250-5, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19632839

Subject(s)

CD4 Antigens/metabolism; HIV Envelope Protein gp120/antagonists & inhibitors; HIV Fusion Inhibitors/chemistry; Isoquinolines/chemistry; Nicotinic Acids/chemistry; Animals; Cells, Cultured; Drug Design; HIV Envelope Protein gp120/metabolism; HIV Fusion Inhibitors/chemical synthesis; HIV Fusion Inhibitors/pharmacokinetics; HIV-1/drug effects; Half-Life; Humans; Isoquinolines/chemical synthesis; Isoquinolines/pharmacokinetics; Nicotinic Acids/chemical synthesis; Nicotinic Acids/pharmacokinetics; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4 Antigens / HIV Envelope Protein gp120 / HIV Fusion Inhibitors / Isoquinolines / Nicotinic Acids Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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