Opipramol, a potent sigma ligand, is an anti-ischemic agent: neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements.

Rao, T S; Cler, J A; Mick, S J; Ragan, D M; Lanthorn, T H; Contreras, P C; Iyengar, S; Wood, P L

Rao, T S; Cler, J A; Mick, S J; Ragan, D M; Lanthorn, T H; Contreras, P C; Iyengar, S; Wood, P L.

Affiliation

Rao TS; CNS Diseases Research, G.D. Searle & Co., Monsanto Company, St Louis, Missouri 63198.

Neuropharmacology ; 29(12): 1199-204, 1990 Dec.

Article in En | MEDLINE | ID: mdl-1963477

Subject(s)

Cerebellum/metabolism; Hippocampus/pathology; Ischemic Attack, Transient/prevention & control; Neurons/pathology; Opipramol/therapeutic use; Receptors, N-Methyl-D-Aspartate/physiology; Receptors, Opioid/physiology; Animals; Cerebellum/drug effects; Cyclic GMP/metabolism; Gerbillinae; Hippocampus/drug effects; Ischemic Attack, Transient/pathology; Ligands; Male; Methamphetamine/pharmacology; Mice; Neurons/drug effects; Opipramol/pharmacology; Pentylenetetrazole/pharmacology; Receptors, N-Methyl-D-Aspartate/drug effects; Receptors, Opioid/drug effects; Receptors, sigma

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Collection: 01-internacional Database: MEDLINE Main subject: Opipramol / Cerebellum / Ischemic Attack, Transient / Receptors, N-Methyl-D-Aspartate / Receptors, Opioid / Hippocampus / Neurons Limits: Animals Language: En Journal: Neuropharmacology Year: 1990 Document type: Article Country of publication: United kingdom

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