Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors.
Arch Orthop Trauma Surg
; 130(7): 819-27, 2010 Jul.
Article
in En
| MEDLINE
| ID: mdl-19636577
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate prospectively, whether integrated 2-deoxy-2-[(18)F]fluoro-D -glucose positron emission tomography-computed tomography (FDG-PET-CT) is more accurate for determination musculoskeletal tumors compared with separate interpretation of CT and FDG-PET, because most of the current clinical data come from patients studied with PET.METHODS:
Eighty patients with newly diagnosed musculoskeletal tumors underwent FDG-PET-CT. CT, FDG-PET, and FDG-PET-CT were interpreted separately to determine the performance of each imaging modality.RESULTS:
Assuming that equivocal lesions are benign, performance of diagnostic tests was as follows sensitivity, specificity and accuracy for CT alone was 81, 84, 83%, for PET 71, 82, 76, and for PET-CT 80, 83 and 86%. Assuming that equivocal lesions are malignant, sensitivity, specificity, and accuracy for CT was 61, 100, 70%, for PET 69, 100, 79, and for PET-CT 69, 100 and 79%.CONCLUSIONS:
Combined FDG-PET-CT reliably differentiates soft tissue and bone tumors from benign lesions. The value of the information provided by FDG-PET-CT for planning surgical procedures must be evaluated in further studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Soft Tissue Neoplasms
/
Bone Neoplasms
/
Tomography, X-Ray Computed
/
Muscle Neoplasms
/
Radiopharmaceuticals
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Arch Orthop Trauma Surg
Year:
2010
Document type:
Article
Affiliation country:
Germany
Publication country:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY