HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.

Moore, Amy E; Greenhough, Alexander; Roberts, Heather R; Hicks, Diane J; Patsos, Helena A; Williams, Ann C; Paraskeva, Christos

Moore, Amy E; Greenhough, Alexander; Roberts, Heather R; Hicks, Diane J; Patsos, Helena A; Williams, Ann C; Paraskeva, Christos.

Affiliation

Moore AE; Cancer Research UK Colorectal Tumour Biology Group, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK.

Carcinogenesis ; 30(10): 1796-804, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19638428

Subject(s)

Adenoma/genetics; Colorectal Neoplasms/genetics; Cyclooxygenase 2/genetics; Hydroxyprostaglandin Dehydrogenases/genetics; Proto-Oncogene Proteins/physiology; Receptors, Growth Factor/physiology; Animals; Cell Line, Tumor; Colorectal Neoplasms/enzymology; Colorectal Neoplasms/therapy; Cyclooxygenase 2/metabolism; Dinoprostone/biosynthesis; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Proto-Oncogene Proteins c-met; Signal Transduction; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenoma / Hydroxyprostaglandin Dehydrogenases / Proto-Oncogene Proteins / Receptors, Growth Factor / Cyclooxygenase 2 Limits: Animals / Humans Language: En Journal: Carcinogenesis Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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