Intravenous immunoglobulin G: trends in production methods, quality control and quality assurance.
Vox Sang
; 98(1): 12-28, 2010 Jan.
Article
in En
| MEDLINE
| ID: mdl-19660029
ABSTRACT
Intravenous immunoglobulin G (IVIG) is now the leading product obtained by fractionation of human plasma. It is the standard replacement therapy in primary and acquired humoral deficiency, and is also used for immunomodulatory therapy in various autoimmune disorders and transplantation. Over the last 30 years, the production processes of IVIG have evolved dramatically, gradually resulting in the development of intact IgG preparations safe to administer intravenously, with normal half-life and effector functions, prepared at increased yield, and exhibiting higher pathogen safety. This article reviews the developments that have led to modern IVIG preparations, the current methods used for plasma collection and fractionation, the safety measures implemented to minimize the risks of pathogen transmission and the major quality control tests that are available for product development and as part of mandatory batch release procedures.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulins, Intravenous
Limits:
Humans
Language:
En
Journal:
Vox Sang
Year:
2010
Document type:
Article
Affiliation country:
France