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19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum.
Traoré-Coulibaly, Maminata; Ziegler, Hanne L; Olsen, Carl Erik; Hassanata, Millogo-kone; Pierre, Guissou I; Nacoulma, Odile G; Guiguemdé, T Rober; Christensen, S Brøgger.
Affiliation
  • Traoré-Coulibaly M; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nat Prod Res ; 23(12): 1108-11, 2009.
Article in En | MEDLINE | ID: mdl-19662575
A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Triterpenes / Rubiaceae / Antimalarials Limits: Animals / Humans Language: En Journal: Nat Prod Res Year: 2009 Document type: Article Affiliation country: Denmark Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Triterpenes / Rubiaceae / Antimalarials Limits: Animals / Humans Language: En Journal: Nat Prod Res Year: 2009 Document type: Article Affiliation country: Denmark Country of publication: United kingdom