Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.

Jaberipour, Mansooreh; Vass, Simon O; Guise, Christopher P; Grove, Jane I; Knox, Richard J; Hu, Longqin; Hyde, Eva I; Searle, Peter F

Jaberipour, Mansooreh; Vass, Simon O; Guise, Christopher P; Grove, Jane I; Knox, Richard J; Hu, Longqin; Hyde, Eva I; Searle, Peter F.

Affiliation

Jaberipour M; Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK.

Biochem Pharmacol ; 79(2): 102-11, 2010 Jan 15.

Article in En | MEDLINE | ID: mdl-19665450

Subject(s)

Mutation; Nitroreductases/genetics; Prodrugs/pharmacology; Animals; Base Sequence; Blotting, Western; DNA Primers; Humans; Mice; Nitroreductases/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nitroreductases / Prodrugs / Mutation Limits: Animals / Humans Language: En Journal: Biochem Pharmacol Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google