Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts.

Chan, Tyani D; Gatto, Dominique; Wood, Katherine; Camidge, Tahra; Basten, Antony; Brink, Robert

Chan, Tyani D; Gatto, Dominique; Wood, Katherine; Camidge, Tahra; Basten, Antony; Brink, Robert.

Affiliation

Chan TD; Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Australia.

J Immunol ; 183(5): 3139-49, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19666691

Subject(s)

Antibody Affinity/immunology; Cell Differentiation/immunology; Cell Movement/immunology; Cell Proliferation; Muramidase/metabolism; Plasma Cells/immunology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Amino Acid Sequence; Animals; Antibody Affinity/genetics; B-Lymphocyte Subsets/immunology; B-Lymphocyte Subsets/metabolism; Cell Differentiation/genetics; Cell Movement/genetics; Immunoglobulin G/biosynthesis; Immunoglobulin M/biosynthesis; Interleukins/deficiency; Interleukins/genetics; Interleukins/physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Muramidase/genetics; Muramidase/immunology; Plasma Cells/cytology; Plasma Cells/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma Cells / T-Lymphocytes / Muramidase / Cell Differentiation / Cell Movement / Cell Proliferation / Antibody Affinity Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2009 Document type: Article Affiliation country: Australia Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google