Type I interferon (IFN alpha) acts directly on human memory CD4+ T cells altering their response to antigen.

Gallagher, Kathleen M E; Lauder, Sarah; Rees, Ian W; Gallimore, Awen M; Godkin, Andrew J

Gallagher, Kathleen M E; Lauder, Sarah; Rees, Ian W; Gallimore, Awen M; Godkin, Andrew J.

Affiliation

Gallagher KM; Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom.

J Immunol ; 183(5): 2915-20, 2009 Sep 01.

Article in En | MEDLINE | ID: mdl-19667099

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Immunologic Memory; Interferon-alpha/physiology; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/drug effects; Cell Proliferation/drug effects; Cells, Cultured; Hemagglutinin Glycoproteins, Influenza Virus/pharmacology; Hepatitis C, Chronic/drug therapy; Hepatitis C, Chronic/immunology; Hepatitis C, Chronic/pathology; Humans; Immunologic Memory/drug effects; Injections, Subcutaneous; Interferon-alpha/administration & dosage; Interferon-alpha/therapeutic use; Leukocytes, Mononuclear/cytology; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/immunology; Lymphocyte Activation/drug effects; Lymphocyte Activation/immunology; Tetanus Toxoid/pharmacology; Tuberculin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Interferon-alpha / Immunologic Memory Limits: Humans Language: En Journal: J Immunol Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United States

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