Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model.

Mastroeni, Roberto; Bensadoun, Jean-Charles; Charvin, Delphine; Aebischer, Patrick; Pujol, Aurora; Raoul, Cédric

Mastroeni, Roberto; Bensadoun, Jean-Charles; Charvin, Delphine; Aebischer, Patrick; Pujol, Aurora; Raoul, Cédric.

Affiliation

Mastroeni R; Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Ann Neurol ; 66(1): 117-22, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19670442

Subject(s)

Adrenoleukodystrophy/complications; Genetic Therapy/methods; Insulin-Like Growth Factor I/genetics; Movement Disorders/etiology; Movement Disorders/therapy; Neurotrophin 3/genetics; ATP Binding Cassette Transporter, Subfamily D; ATP-Binding Cassette Transporters/genetics; Adrenoleukodystrophy/genetics; Analysis of Variance; Animals; Behavior, Animal/physiology; Chemokine CCL22/deficiency; Dependovirus/genetics; Disease Models, Animal; Gene Transfer Techniques; Green Fluorescent Proteins/genetics; Humans; Insulin-Like Growth Factor I/cerebrospinal fluid; Mice; Mice, Knockout; Neurotrophin 3/cerebrospinal fluid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Genetic Therapy / Adrenoleukodystrophy / Neurotrophin 3 / Movement Disorders Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Ann Neurol Year: 2009 Document type: Article Affiliation country: Switzerland Country of publication: United States

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