Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-antitrypsin.

Montecucco, Fabrizio; Bertolotto, M; Ottonello, L; Pende, A; Dapino, P; Quercioli, A; Mach, F; Dallegri, F

Montecucco, Fabrizio; Bertolotto, M; Ottonello, L; Pende, A; Dapino, P; Quercioli, A; Mach, F; Dallegri, F.

Affiliation

Montecucco F; Division of Cardiology, Foundation for Medical Researches, Department of Medicine, Geneva University Hospital, Geneva, Switzerland. fabrizio.montecucco@unige.ch

Clin Exp Pharmacol Physiol ; 36(11): e72-7, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19671069

Subject(s)

Anti-Inflammatory Agents/pharmacology; Chlorhexidine/analogs & derivatives; Neutrophil Activation/drug effects; Neutrophils/drug effects; alpha 1-Antitrypsin/metabolism; Cells, Cultured; Chlorhexidine/pharmacology; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Humans; Hypochlorous Acid/antagonists & inhibitors; Hypochlorous Acid/metabolism; Hypochlorous Acid/pharmacology; Models, Immunological; Neutrophils/enzymology; Neutrophils/metabolism; Peroxidase/metabolism; Superoxides/metabolism; Tetradecanoylphorbol Acetate/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorhexidine / Alpha 1-Antitrypsin / Neutrophil Activation / Anti-Inflammatory Agents / Neutrophils Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Exp Pharmacol Physiol Year: 2009 Document type: Article Affiliation country: Switzerland

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