Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cells.

Saleem, Mohammad; Murtaza, Imtiyaz; Witkowsky, Olya; Kohl, Amanda Marie; Maddodi, Nityanand

Saleem, Mohammad; Murtaza, Imtiyaz; Witkowsky, Olya; Kohl, Amanda Marie; Maddodi, Nityanand.

Affiliation

Saleem M; School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, MSC # 4385, Madison, WI 53719, USA. msbhat@wisc.edu

Biochem Biophys Res Commun ; 388(3): 576-82, 2009 Oct 23.

Article in En | MEDLINE | ID: mdl-19683515

Subject(s)

CASP8 and FADD-Like Apoptosis Regulating Protein/antagonists & inhibitors; Microtubule-Associated Proteins/antagonists & inhibitors; Microtubules/drug effects; Prostatic Neoplasms/metabolism; Triterpenes/pharmacology; Tubulin Modulators/pharmacology; Animals; Apoptosis/genetics; CASP8 and FADD-Like Apoptosis Regulating Protein/biosynthesis; Cell Cycle/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Diet; Humans; Inhibitor of Apoptosis Proteins; Male; Mice; Microtubule-Associated Proteins/biosynthesis; Microtubule-Associated Proteins/metabolism; Microtubules/metabolism; Pentacyclic Triterpenes; Survivin; Transcriptional Activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Triterpenes / Tubulin Modulators / CASP8 and FADD-Like Apoptosis Regulating Protein / Microtubule-Associated Proteins / Microtubules Limits: Animals / Humans / Male Language: En Journal: Biochem Biophys Res Commun Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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