Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory.

Xue, Wei; Hu, Jin-feng; Yuan, Yu-he; Sun, Jian-dong; Li, Bo-yu; Zhang, Dong-ming; Li, Chuang-jun; Chen, Nai-hong

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory.

Xue, Wei; Hu, Jin-feng; Yuan, Yu-he; Sun, Jian-dong; Li, Bo-yu; Zhang, Dong-ming; Li, Chuang-jun; Chen, Nai-hong.

Affiliation

Xue W; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Acta Pharmacol Sin ; 30(9): 1211-9, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19684611

Subject(s)

Hippocampus/drug effects; Maze Learning/drug effects; Memory/drug effects; Nootropic Agents/pharmacology; Polygala/chemistry; Saponins/pharmacology; Triterpenes/pharmacology; Animals; Brain-Derived Neurotrophic Factor/biosynthesis; Cyclic AMP Response Element-Binding Protein/metabolism; Dentate Gyrus/drug effects; Evoked Potentials/drug effects; Extracellular Signal-Regulated MAP Kinases/metabolism; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Nootropic Agents/isolation & purification; Phosphorylation/drug effects; Rats; Rats, Wistar; Saponins/isolation & purification; Synapsins/metabolism; Synaptic Transmission/drug effects; Triterpenes/isolation & purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Triterpenes / Nootropic Agents / Maze Learning / Polygala / Hippocampus / Memory Limits: Animals Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2009 Document type: Article Affiliation country: China Country of publication: United States

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