Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension.
J Gastroenterol Hepatol
; 24(12): 1852-6, 2009 Dec.
Article
in En
| MEDLINE
| ID: mdl-19686417
ABSTRACT
BACKGROUND AND AIM:
Although prophylaxis with beta-blockers has been shown to decrease variceal pressure and wall tension in cirrhotic patients, this has not been demonstrated in non-cirrhotic portal hypertension caused by Schistosoma mansoni infection.METHODS:
Thirteen patients without history of previous gastrointestinal bleeding were included. All of them had high-risk esophageal varices at endoscopy. An endoscopic gauge and a high-frequency endoscopic ultrasonography miniprobe were used to assess transmural variceal pressure and wall tension before and after achieving beta-blockade with propranolol.RESULTS:
Baseline variceal pressure decreased from 13.3 +/- 3.5 to 8.2 +/- 2.0 mmHg (P < 0.0001) and wall tension from 500.2 +/- 279.8 to 274.0 +/- 108.3 mg.mm(-1). The overall effect of propranolol on decreasing variceal pressure and wall tension expressed in percentage change in relation to baseline values was 35.7 +/- 18.4% and 35.9 +/- 26.7%, respectively (P = 0.9993).CONCLUSION:
Propranolol significantly reduced variceal pressure and wall tension in schistosomiasis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propranolol
/
Venous Pressure
/
Schistosomiasis mansoni
/
Esophageal and Gastric Varices
/
Adrenergic beta-Antagonists
/
Gastrointestinal Hemorrhage
/
Hypertension, Portal
Limits:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Gastroenterol Hepatol
Journal subject:
GASTROENTEROLOGIA
Year:
2009
Document type:
Article
Affiliation country:
Brazil