Mediastinal Kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon in an infant: treatment with interferon.
J Pediatr Hematol Oncol
; 31(9): 690-2, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19687760
ABSTRACT
A 2-week-old infant developed respiratory failure due to a mediastinal Kaposiform hemangioendothelioma that was complicated by thrombocytopenia and consumptive coagulopathy. Initial surgery was unsuccessful at removing the tumorous infiltration of mediastinal structures. Multiple transfusions with fresh frozen plasma, platelets, and red blood cells were needed for the consumptive coagulopathy, and ventilatory support was required for 5 months. Therapy for the tumor included methylprednisolone, aminocaproic acid, and vincristine, but a sustained response was achieved only after the initiation of alpha interferon. The patient was monitored closely and did not develop neurologic toxicity. This case demonstrates that interferon can be used to treat infants with Kaposiform hemangioendothelioma in life-threatening situations that do not respond to other forms of treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Insufficiency
/
Thrombocytopenia
/
Antineoplastic Combined Chemotherapy Protocols
/
Interferon-alpha
/
Disseminated Intravascular Coagulation
/
Hemangioendothelioma
/
Anemia, Hemolytic
/
Mediastinal Neoplasms
Limits:
Female
/
Humans
/
Newborn
Language:
En
Journal:
J Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2009
Document type:
Article
Affiliation country:
United States