Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy.
Br J Ophthalmol
; 93(11): 1539-45, 2009 Nov.
Article
in En
| MEDLINE
| ID: mdl-19692381
ABSTRACT
BACKGROUND/AIM:
Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated.METHODS:
TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding (>1 week) retinal detachment (n = 29), fresh (<1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used.RESULTS:
Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) than in pseudophakic patients (median 12 mg/l; IQR 8 to 19 mg/l; p = 0.06). Postoperative change in visual acuity correlated well with vitreous TTR values found peroperatively (r(s) = 0.408; p = 0.012). Both change in visual acuity and lens status were the only variables which proved to explain the variance of TTR (multiple correlation coefficient 0.494; phakic status t = 2.767; p = 0.0084; and change in visual acuity t = 2.924 p = 0.0056).CONCLUSION:
Vitreous fluid concentrations of TTR can be regarded as a biochemical marker for retinal function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Vision Disorders
/
Vitrectomy
/
Vitreous Body
/
Prealbumin
/
Visual Acuity
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Ophthalmol
Year:
2009
Document type:
Article
Affiliation country:
Belgium